Lexotanil Bromazepam 3 mg

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Lexotanil Bromazepam 3 mg

Lexotanil Bromazepam 3 mg Therapeutic/Pharmacologic Class of Drug: Anxiolytic.
Type of Dosage Form: Tablets. Route of Administration: Oral.


Bromazepam is extensively metabolised in the liver. No metabolites with a half-life longer than that of the parent drug are formed. Quantitatively, two metabolites dominate: 3-hydroxy-bromazepam (less active than bromazepam) and 2-(2-amino-5-bromo-3-hydroxybenzoyl) pyridine (inactive). Bromazepam is metabolized, at least in part, through cytochrome P450 (CYP450). However, the specific CYP isozymes involved have not been identified. Nevertheless, the observations that a strong CYP3A4 inhibitor (itraconazole) and a moderate CYP2C9 inhibitor (fluconazole) had no effect on the pharmacokinetics of bromazepam suggest that these isozymes are not involved to a major extent. The pronounced interaction with fluvoxamine (see Interactions with other Medicinal Products and other Forms of Interaction–Pharmacokinetic drug-drug interaction) points to the co-involvement of CYP1A2.


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