Ephedrine, Mormon Tea, Primatene, Bronchlate

Ephedrine, Mormon Tea, Primatene, Bronchlate  is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma.

Pharmacodynamic properties

Pharmacotherapeutic group: Adrenergic & Dopaminergic Agent, ATC Code: C01CA26 Ephedrine is a sympathomimetic amine acting directly on the alpha and beta receptors and indirectly by increasing the release of noradrenaline by the sympathetic nerve endings. As with any sympathomimetic agent, ephedrine stimulates the central nervous system, the cardiovascular system, the respiratory system, and the sphincters of the digestive and urinary systems. Ephedrine is also a monoamine oxidase (MAO) inhibitor.

Pharmacokinetic properties

After intravenous administration, ephedrine is completely biologically available, and after oral administration, the bioavailability of ephedrine has been reported to be above 90%. Excretion depends on urine pH: From 73 to 99% (mean: 88%) in acidic urine, From 22 to 35% (mean: 27%) in alkaline urine. After oral or parenteral administration, 77% of ephedrine is excreted in unchanged form in the urine. The half-life depends on urine pH. When the urine is acidified at pH = 5, the half-life is 3 hours; when the urine is rendered alkaline at pH = 6.3, the half-life is approximately 6 hours.

Do not use ephedrine if:

  • you are allergic to this medication.
  • you do not have a diagnosis of asthma
  • you have a diagnosis of asthma but use prescription asthma medications
  • if you have ever been hospitalized for asthma
  • you are taking a monoamine oxidase (MAO) inhibitor (eg, phenelzine) now or have taken an MAO inhibitor in the last 14 days. If you do not know if your prescription drug contains an MAO inhibitor, ask your health care provider before taking this product.
  • you have high blood pressure, heart disease, an irregular heartbeat, thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland or other severe heart problems

Contact your doctor or health care provider before using ephedrine if any of these apply to you.

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