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Actos 30 mg (Pioglitazone) tablets

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Description

Actos 30 mg (Pioglitazone)

Actos 30 mg (Pioglitazone)  is an oral antidiabetic agent that acts primarily by decreasing insulin resistance.

Absorption:

Following oral administration, in the fasting state, pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within 2 hours. Food slightly delays the time to peak serum concentration to 3 to 4 hours, but does not alter the extent of absorption.

Distribution:

The mean apparent volume of distribution (Vd/F) of pioglitazone following single-dose administration is 0.63 + 0.41 (mean + SD) L/kg of body weight. Pioglitazone
is extensively protein bound (>99%) in human serum, principally to serum albumin. Pioglitazone also binds to other serum proteins, but with lower affinity. Metabolites M-III and M-IV also are extensively bound (>98%) to serum albumin.

Hepatic Insufficiency:

Compared with normal controls, subjects with impaired hepatic function (Child-Pugh Grade B/C) have an approximate 45% reduction in pioglitazone and total pioglitazone mean peak concentrations but no change in the mean AUC values

 

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