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Actimmune (interferon gamma-1b) vials (0.5ml)

$1,875.45 $1,011.81

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Description

Actimmune (interferon gamma-1b) vials (0.5ml) of 100mcg

Actimmune (interferon gamma-1b) vials (0.5ml) of 100mcg Interferon gamma is used to treat chronic granulomatous disease and severe osteoporosis. It helps support the immune system to fight infection.

INDICATIONS AND USAGE

ACTIMMUNE is an interferon gamma indicated for:

• Reducing the frequency and severity of serious infections associated with Chronic Granulomatous Disease (CGD).

• Delaying time to disease progression in patients with severe, malignant osteopetrosis(SMO).

DOSAGE AND ADMINISTRATION

Actimmune (interferon gamma-1b) vials (0.5ml) of 100mcg

Actimmune (interferon gamma-1b) vials (0.5ml) of 100mcg

 

• The recommended dose is 50 mcg/m2 for patients whose body surface area is greater than 0.5 m2 and 1.5 mcg/kg/dose for patients whose body surface area is equal to or less than 0.5 m2 three times weekly.

• Monitor hematology, blood chemistries and urinalysis prior to the beginning of treatment and at 3-month intervals.

• If severe reactions occur, reduce dose by 50 percent or discontinue therapy until the adverse reaction abates.

DOSAGE FORMS AND STRENGTHS

Injection: 100 mcg (2 million International Units) of Interferon gamma-1b in 0.5 mL solution in a single use vial.

CONTRAINDICATIONS

Known hypersensitivity to interferon gamma, E. coli derived products, or any

component of the product.

DRUG INTERACTIONS

• Concomitant use of drugs with neurotoxic, hematotoxic or cardiotoxic effects may increase the toxicity of interferons.

• Avoid simultaneous administration of ACTIMMUNE with other heterologous serum protein or immunological preparations.

Hypersensitivity Reactions

Isolated cases of acute serious hypersensitivity reactions have been observed in patients receiving ACTIMMUNE. If such an acute reaction develops the drug should be discontinued immediately and appropriate medical therapy instituted. Transient cutaneous rashes have occurred in some patients following injection of ACTIMMUNE that have necessitated treatment interruption.

Renal Toxicity

Monitor renal function regularly when administering ACTIMMUNE in patients with severe renal insufficiency because the possibility exists that with repeated administration, accumulation of interferon gamma-1b may occur. Renal toxicity has been reported in patients receiving ACTIMMUNE.

Allergic Reactions to Natural Rubber

The stopper of the glass vial for ACTIMMUNE contains natural rubber (a derivative of latex) which may cause allergic reactions.

ADVERSE REACTIONS

Common adverse reactions (incidence rate 2% or greater) for ACTIMMUNE include fever, headache, rash, chills, injection site erythema or tenderness, fatigue, diarrhea.

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